We have been studying Middle English alliterative verse for over a century, but so far we lack an authoritative description of the rhythmic constraints that governed the poets who wrote alliterative verse. Though some scholars have tried to show the survival of Sievers's five types, few editors have dared, in the absence of a comprehensive and authoritative account of the meter, to emend or choose between the variants in the manuscripts on metrical grounds. Two factors largely account for this state (...) of affairs: the apparent variety of the verse form itself and the failure of students of the meter to distinguish the practices of poets from those of the scribes. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:THE INSCRUTABILITY O:F MORAL EVIL IN KANT ((W:HENCE COMETH EVIL?" Late in his career, Immanuel Kant would turn his attention to this perennial question with an elaborate account of " radical evil " in Religion within the Limits of Reason Alone. His discussion produced consternation among his admirers, such as Goethe, and continues to produce puzzlement among his commentators. Among the chief difficulties facing the modern-day interpreter has been (...) the welter of complex terminology tossed up by Kant's attempts to tame his topic. The Kant specialist can justifiably suppose that if only he or she could un-scramble the terminology, grasp the intended interconnections among the terms, and set the discussion within the context of the entire critical philosophy, the result would be a reasonably clear view of Kant's theory of the nature and source of moral evil. There is of course some justification to this vaguely masochistic approach to the matter, yet such an approach, I fear, leads inevitably to frustration. This is because, despite all the appearances to the contrary, Kant never really explains moral evil in the discussion of radical evil in Religion. To be sure, he offers a definition of what moral evil is, by the terms of his philosophy. Nevertheless, he never really accounts for evil, nor does he offer anything remotely approaching an answer to my opening question. The deepest part of Kant's analysis is not a response to that question, but a link between moral evil and human freedom, and this link is utterly inexplicable, for the same reason that freedom itself is, for Kant, ultimately inexplicable. Thus, by this reading of the theory of radical evil, we are not finally led to comprehend Kant's view of evil. Instead, we are 246 THE INSCRUTABILITY OF MORAL EVIL IN KANT 247 reminded of the contingent nature of the exercise of freedom, the unfathomable quality of the process of character-building, and, finally, the sheer inscrutability of moral evil itself. Kant is theorizing about human nature in a way that gradually discloses the futility of domesticating this topic conceptually or rationally. This point is worth stressing, partly because of certain stereotypes that persist regarding the things Kant's philosophy supposedly renders in rational form. And, obviously, the point can be stressed in the present context by pursuing further the notion that moral evil is, for Kant, inscrutable. The inscrutability of moral evil does not pop into view all at once, for Kant's discussion in Religion is set in the context of a complex account of the structure of the will, the nature of the incentives capable of determining the will, and the issue of freedom. Consequently, in what follows I shall attempt to trace the Kantian line of thought lying behind his agnosticism regarding the source of moral evil. -IFor Kant, moral evil resides in a maxim.1 A maxim is for him a special kind of principle, one which guides or informs actionin effect, a "practical principle." The very idea of a maxim is a key element in Kant's efforts to determine how reason can be practical. Discourse about maxims is Kant's way of accounting for those practical principles by which we actually do act, instead of only those principles by which we ought ideally to act.2 In effect, a maxim is the guiding principle that I could state to myself were I to reflect upon the overall policy determining a given act (" I should enrich myself by whatever 1 Kant, Die Religion innerhalb der Grenzen der blossen Vernunft, ed. W. Weischedel (Frankfurt am Main: Suhrkamp, 1978), p. 6*7. English translation, Religion within the Limits of Reason Alone, trans. Theodore M. Greene and Hoyt H. Hudson (New York: Harper and Row, 1960), p. 17. Hereafter referred to as Religion, followed by page numbers in both Weischedel and Greene/Hudson, with all translations taken from the latter. 2 Kant, Foundations of the Metaphysics of Morals. trans. Lewis White Beeck, (New York: Bobbs-Merrill, 1950), pp. 17 n.l, 38 n.9. Q48 GORDON E. MICHALSON means possible," " I should at all times tell the truth "). This distinction between guiding principles by which we actually do... (shrink)

On one way of talking about a traditional metaethical topic, realists accept that some items appear on the list of what exists in the moral or more broadly normative domain of inquiry. They then divide over whether those items are like what science and experience suggest that all other items on the list of what exists across all domains are like – naturalistic and secular. Reductive naturalists answer this further question affirmatively. Why don’t nonnaturalists? I explore the answer that it’s (...) because normative entities are “just too different” in the sense that they are countably different things. However, I argue that this answer rests on the subtle presupposition that the normative domain doesn’t also contain uncountable entities of the sort that analytic metaphysicians call “stuff”. Taking intuitions of difference seriously points the way to a novel form of metaethical reductive naturalism. The key is to identify the stuff that matters. (shrink)

In the past 25 years or so, the issue of ethical universalizability has figured prominently in theoretical as well as practical ethics. The term, 'universaliz ability' used in connection with ethical considerations, was apparently first introduced in the mid-1950s by R. M. Hare to refer to what he characterized as a logical thesis about certain sorts of evaluative sentences (Hare, 1955). The term has since been used to cover a broad variety of ethical considerations including those associated with the ideas (...) of impartiality, consistency, justice, equality, and reversibility as well as those raised in the familar questions: 'What if everyone did that?' and 'How would you like it if someone did that to you? But this recent effloresence of the use of the term 'universalizability' is something that has deep historical roots, and has been central in various forms to the thinking about morality of some of the greatest and most influential philosophers in the western tradition. While the term is relatively new, the ideas it is now used to express have a long history. Most of these ideas and questions have been or can be formulated into a principle to be discussed, criticized, or defended. As we discuss these ideas below this prin ciple will be stated on a separate numbered line. The concepts of justice and equality were closely linked in Greek thought. These connections between these two concepts are apparent even in two authors who were hostile to the connection, Plato and Aristotle. (shrink)

Mathematical pluralism can take one of three forms: (1) every consistent mathematical theory consists of truths about its own domain of individuals and relations; (2) every mathematical theory, consistent or inconsistent, consists of truths about its own (possibly uninteresting) domain of individuals and relations; and (3) the principal philosophies of mathematics are each based upon an insight or truth about the nature of mathematics that can be validated. (1) includes the multiverse approach to set theory. (2) helps us to understand (...) the significance of the distinguished non‐logical individual and relation terms of even inconsistent theories. (3) is a metaphilosophical form of mathematical pluralism and hasn't been discussed in the literature. In what follows, I show how the analysis of theoretical mathematics in object theory exhibits all three forms of mathematical pluralism. (shrink)

Le concept de conflit revêt divers aspects. Entre les litiges, les violences, les différends, les désaccords, les guerres, il importe de définir les éléments de la conflictualité et le caractère institutionnel des recherches en matière de gestion et de résolution des conflits de nos jours. Néanmoins, nous sommes parvenus à percevoir que la clé du succès des résolutions des conflits pour une paix durable réside dans l’expérience humaine de la culpabilité et du pardon. Ce n’est certes pas des éléments nouveaux (...) pour les spécialistes et les diplomates en matière de gestion des conflits. Cependant, Ces deux notions sont reléguées au second plan au profit de compromis et de mesures coercitives à l’encontre des factions en conflits. Notre vision de la résolution des conflits est que sans la mise en exergue de l’expérience de la culpabilité et du pardon, les peuples vivront dans un conflit perpétuel qu’ils transmettront aux générations futures : la haine durable (sustainablehate). Est-il possible d’institutionnaliser le pardon et de mener des actions conduisant à une véritable culpabilité collective et individuelle préalable à toute réconciliation durable des peuples? La nature et la fréquence de nos conflits obligent à reconsidérer les méthodes d’approche jusqu’ici utilisées. En effet, c’est ce que tentent de faire certaines commissions pour la réconciliation appelée pour la plupart « Dialogue – Vérité – Réconciliation ; Dialogue – Justice – Réconciliation ; justice et paix, etc ». où les belligérants, les bourreaux et les victimes sont invités à l’aveu, à la vérité et au pardon pour un re-vivre ensemble. Mais dans l’espace d’un processus de réconciliation engagé à travers desdites commissions, les ballets de confessions aussi bien que les sentiments de victimisation se succèdent avant à l’arrière fond l’amnistie pour les bourreaux et l’octroi du pardon de la part des victimes. Cela, parait peu convainquant pour la raison que ces commissions sont en majeure partie installées par les vainqueurs du moment. Dans une certaine Afrique surtout, ces derniers (les vainqueurs) sont aidés par des alliés occidentaux de hauts niveaux. Il s’agit alors de processus où la paix est provisoire et se maintient au bout de la force ; et où les bourreaux sont toujours les autres. (shrink)

En este artículo, se examinará la visión de Foucault del cuerpo y el surgimiento del cuerpo como un elemento indispensable del poder político. Por lo tanto, se discutirá cómo se objetiva la organización en períodos de poder disciplinario y regulatorio. En el contexto de la regulación del poder, trataremos de mostrar qué dinámica básica corresponde el alma, que es la prisión del cuerpo, al poder y al cuerpo. En ambos períodos, vemos que el poder elie el cuerpo como espacio. El (...) cuerpo representa el cuerpo de la sociedad y funciona como tal. En el estudio, se examinará la captura del alma como un elemento que afecta, moldea, cambia y transforma el cuerpo en la comprensión del poder regulador después del poder disciplinario. En última instancia, dado que este esfuerzo da como resultado la producción de nuevas dinámicas de poder, se intentará mostrar en un contexto crítico que el poder no permite ningún cambio, transformación y mejora de individuos y criminales a quienes percibe como cuerpos. (shrink)

Avicenna holds that since God has existed from all eternity and is immutable and impassible, he cannot come to have an attribute or feature that he has not had from all eternity. He also claims for the simultaneous causation. A puzzle arises when we consider God’s creating this world. If God is immutable and impassible, then his attributes associated with his creating this world are unchanging. So, God must have been creating the world from all eternity. But then God’s creative (...) act, one might object, seems to be no different from a matter of natural necessity. This is a threat to divine freedom, for God would then have no choice concerning his creative action. Anthony Ruffus and Jon McGinnis argue that this puzzle can be solved in such a way that Avicenna can consistently affirm divine freedom along with divine simplicity. They suggest that Naṣīr al-Dīn Ṭūsī’s interpretation might help to show that it is false that Avicenna’s God cannot choose absolutely. For it is still open to him to choose either to create eternally or to refrain from creating anything at all. Ruffus and McGinnis argue that since creating or not creating anything at all do not correspond to two distinct concepts, Avicenna’s account of divine simplicity, which denies any multiplicity in divine mind, is safeguarded along with divine freedom. I claim that God’s omnirationality requiring that he always acts for reasons is a serious threat to such an interpretation. (shrink)

Using mobile health research as an extended example, this article provides an overview of when the Common Rule “applies” to a variety of activities, what might be meant when one says that the Common Rule does or does not “apply,” the extent to which these different meanings of “apply” matter, and, when the Common Rule does apply, how it applies.

© 2019 The Author. Background: The phenomenon of being 'with woman' is fundamental to midwifery as it underpins its philosophy, relationships and practices. There is an identified gap in knowledge around the 'with woman' phenomenon from the perspective of midwives providing care in a variety of contexts. As such, the aim of this study was to explore the experiences of being 'with woman' during labour and birth from the perspective of midwives' working in a model where care is provided by (...) a known midwife. Methods: A descriptive phenomenological design was employed with ten midwives working in a 'known midwife' model who described their experiences of being 'with woman' during labour and birth. The method was informed by Husserlian philosophy which seeks to explore the same phenomenon through rich descriptions by individuals revealing commonalities of the experience. Results: Five themes emerged 1) Building relationships; 2) Woman centred care; 3) Impact on the midwife; 4) Impact on the woman; and 5) Challenges in the Known Midwife model. Midwives emphasised the importance of trusting relationships while being 'with woman', confirming that this relationship extends beyond the woman - midwife relationship to include the woman's support people and family. Being 'with woman' during labour and birth in the context of the relationship facilitates woman-centred care. Being 'with woman' influences midwives, and, it is noted, the women that midwives are working with. Finally, challenges that impact being 'with woman' in the known midwife model are shared by midwives. Conclusions: Findings offer valuable insight into midwives' experiences of being 'with woman' in the context of models that provide care by a known midwife. In this model, the trusting relationship is the conduit for being 'with woman' which influences the midwife, the profession of midwifery, as well as women and their families. Descriptions of challenges to being 'with woman' provide opportunities for professional development and service review. Rich descriptions from the unique voice of midwives, provided insight into the applied practices of being 'with woman' in a known midwife model which adds important knowledge concerning a phenomenon so deeply embedded in the philosophy and practices of the profession of midwifery. (shrink)

This comparative study delves into the concepts of contemporary feminism and Islamic perspectives on gender equality and women’s rights, aiming to identify similarities, differences, and areas of convergence between the two frameworks globally. Drawing on a diverse range of feminist theories and Islamic sources, the study analyses key concepts, principles, and practices related to gender equality, women’s rights, and empowerment. Additionally, the article explores the inclusion of feminist perspectives from Sufism, further enriching the discourse on gender dynamics. By examining the (...) intersections and tensions between these frameworks, the study contributes to a deeper understanding of the complexities surrounding gender equality discourse and ongoing conversations on women’s rights within diverse cultural and religious contexts. Objectives of the Study: To do a comparative study and explore the contemporary concepts and Islamic perspectives on gender equality with incorporation of feminist ideals within Sufism. (shrink)